NEW APPROACHES FOR THE FACILE AND EFFICIENT PREARATION OF ADVANCED FUNCTIONAL HYDROPHILIC MOLECULARLY IMPRINTED POLYMER NANOPARTICLES
As tailor-made synthetic receptors with high affinity and selectivity towards target analytes, molecularly imprinted polymer (MIP) nanoparticles have attracted rapidly increasing interest in recent years because of their great potential as substitutes for biological receptors in such applications as chemosensing, immunoassay, biomedicine, drug delivery, and theranostics. In particular, development of advanced functional hydrophilic MIP nanoparticles that can selectively recognize small organic analytes in complex aqueous milieus is of significant importance because food safety control, environmental monitoring, and biomedical applications are typically based on aqueous systems.1
Over the past few years, our group has successfully developed some versatile one-pot approaches (namely hydrophilic macromolecular chain transfer agent/initiator-induced controlled/“living” radical precipitation polymerization (CRPP)) for the controlled synthesis of hydrophilic functional MIP nanoparticles capable of selectively recognizing small organic analytes in complex biological media, which proved to be highly promising in various bioanalytical and biomedical applications.2-5 To further improve the comprehensive performance of such MIP nanoparticles, we have recently developed a facile and efficient strategy for preparing well-defined hydrophilic functional hollow MIP submicro- or nanoparticles with largely improved template binding properties as well as better flexibility and higher water-dispersity, which involves the first synthesis of “living” and easily etchable polymer submicro- or nanoparticle cores via CRPP, their controlled surface-grafting of MIP and hydrophilic polymer layers, and subsequent removal of the cores by solvent-washing.6 In this lecture, we will present our progress in the development of these advanced functional hydrophilic MIP nanoparticles.
References
- Zhang H (2018) Water-compatible molecularly imprinted polymers.Molecularly Imprinted Polymers for Analytical Chemistry Applications. Eds. Kutner W and Sharma PS, RSC.
- Ma Y, Pan G, Zhang Y, Guo X, Zhang H (2013) Narrowly dispersed hydrophilic molecularly imprinted polymer nanoparticles for efficient molecular recognition in real aqueous samples. Angewandte Chemie International Edition 52: 1511-1514.
- Ma Y, Li H, He S, Zhang HT, Zhang H (2014) Efficient one-pot synthesis of water-compatible and photoresponsive molecularly imprinted polymer nanoparticles by facile RAFT precipitation polymerization. Journal of Polymer Science, Part A: Polymer Chemistry 52: 1941-1952.
- Niu H, Yang Y, Zhang H (2015) Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples Biosensors and Bioelectronics 74: 440-446.
- Yang Y, Wang Z, Niu H, Zhang H (2016) One-pot synthesis of quantum dot-labeled hydrophilic molecularly imprinted polymer nanoparticles for direct optosensing of folic acid in real, undiluted biological samples. Biosensors and Bioelectronics 86: 580-
- Zhang H, et al. Manuscript in preparation.
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