A TECHNIQUE OF DRUG DESIGNING BY MOLECULAR IMPRINTING IN WATER-ETHYL ALCOHOL SUPRA-MOLECULAR MATRIX USING BIOLOGICAL LIGANDS, PATHOGENIC MOLECULES OR PROTEIN INHIBITOR DRUGS AS TEMPLATES

Abstract: In the seminal article introducing the idea of ‘molecular imprinted polymers’
published in Nature in 1993, the group of Klaus Mosbach had hypothesized molecular imprinted
materials could one day provide a “useful, general alternative to antibodies”, and called them
“antibody mimics”. Even though molecular imprinting technology has made great strides during
the past 23 years since the publication of that article, and MIPs succeeded in being widely used
as an alternative to antibodies in competitive binding assays, their prophecy did not materialize
in its full meaning as a ‘general alternative to antibodies’. Being polymer-based preparations,
MIPs could not be so far used as an alternative to antibodies inside the living bodies due to safety
concerns originating from issues related with absorption, metabolism, elimination, stability,
toxicity etc.

In this present article, authors introduce a novel technique of drug designing, wherein
Molecular Imprinted Artificial Ligand Binds (MIALBs) could be synthesized by a process of
molecular imprinting in water-ethyl alcohol supra-molecular matrices using endogenous
biological receptor ligands, pathogenic molecules or protein inhibitor drug molecules as
templates. This technique is expected to pave way to the development of a whole new range of
safe and effective prophylactic as well as therapeutic designer drugs against almost every disease
where the underlying molecular mechanism of pathology is known. This new technique will
obviously lead also to the materialization of the twenty years old prophecy of our forerunners
regarding molecular imprinted materials as a “useful, general alternative to antibodies”.

This article consists of only the introductory conceptual part of the proposed Molecular
Imprinted Artificial Ligand Binds (MIALBs) technique of Drug Designing by molecular
imprinting in water-ethyl alcohol matrix. Experimental and Technical part of this work will be
published very shortly as a separate research paper once the ongoing in-vitro and in-vivo studies
are concluded and analyzed. Once completed, this work is expected to open up great new
avenues of researches in the field of Molecular Imprinting that may lead to a total revamping of
whole pharmaceutical industry.