Ultrasound Applications in Gene Therapy

As modern medicine discerns more mechanisms, both of physiology and of pathophysiology, the approach to healing is to mimic, or if possible, to recreate the physiology of healthy functioning. Thus, the area of bio-nano polymers for targeted drug and gene delivery has evolved. The main objective of gene therapy is the development of efficient, non-toxic gene carriers that can condense and deliver foreign genetic materials into specific cell types. . Viral and non-viral carriers have been developed and some already have been approved for cancer and blindness. Still in many studies, the transfection efficiency is too low due to biological barriers in the transfection process. One example is Psoriasis a chronic inflammatory skin disease that affects 3% of the population, yet. safe and effective topical therapy is still lacking for this disease. Although miRNA have the potential for treating psoriasis, its topical delivery to the depth of the epidermis is challenging due to the barrier properties of the top layer of the skin and the cell membrane. To overcome these obstacles and allow topical delivery of miRNA to skin cells, we suggested the use of a modified cationic polysaccharide carrier and ultrasound (US) as a mean to enhance biological membrane’s permeability (skin and cell), In the presentation studies on the application of ultrsuond and polymeric carrires in gene therapy would be presented.