The Association between Neck Adiposity and Long-Term Outcome

Isai Altshuler 1 Sigal Tal 1,2 Miriam Klar M. 1,2 Sa’ar Minha 2,3
1Department of Radiology, Assaf Harofeh Medical Center, Israel
2Sackler Faculty of Medicine, Tel-Aviv University, Israel
3Department of Cardiology, Assaf Harofeh Medical Center, Israel

ABSTRACT INTRODUCTION: Anthropometric indices of obesity (e.g. body mass index, waist circumference and neck circumference) are associated with poor long-term cardiovascular outcome. Prior studies have associated between neck circumference and central body adiposity. We explored the association between neck fat volume (NFV) and long-term outcome.

METHODS: Retrospective analysis of all patients undergoing computerized tomography angiography for suspected cerebrovascular accident between January and December 2013. NFV was assessed by three dimensional reconstructions and was adjusted to height to account for differences in body sizes, thus yielding the NFV/height ratio (NHR). Univariate and multivariate analysis were utilized to explore the association between various indices including NHR and all-cause mortality.

RESULTS: This analysis included 302 patients. The average age was 61.9±14.3 years, 60.6% of whom were male. Diabetes mellitus, hypertension and cardiovascular disease were frequent in 31.5%, 69.9%, and 72.2% of patients, respectively. The median NHR was 492.53cm2 [IQR 393.93-607.82]. Median follow up time was 41.2 months, during which 40 patients (13.2%) died. Multivariate analysis adjusting for age, sex, and diabetes mellitus indicated an independent association between the upper quartile of NHR and all-cause mortality (hazard ratio= 2.279; 95% CI= 1.209-4.299; p =.011).

CONCLUSION: NHR is a readily available anthropometric index that significantly correlated with poor long-term outcome. Following validation in larger scale studies, this index may serve a risk stratifying tool for cardiovascular disease and future outcome.

Isai Altshuler
Isai Altshuler








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