PURPOSE: To correlate ultrasonographic parameters with histopathological findings in renal parenchymal disease.
MATERIALS/METHOD: This cross sectional hospital based observational study was conducted at Bir Hospital, National academy of Medical Sciences, Kathmandu, Nepal .A total 54 patients admitted in the nephrology ward were included in the study. Sonographic parameters (length, echogenicity, cortical thickness, parenchymal thickness and resistive index) were correlated with the biopsy findings of glomerular sclerosis, tubular atrophy, interstitial fibrosis, and interstitial inflammation. Univariate analysis is presented as Spearman correlation coefficients. Multivariate analysis was done with SPSS 16 software.
RESULTS: The mean age of the participants in the study was 32.4 years. Similarly the mean length of kidney was 9.8cm, cortical thickness 1 cm and parenchymal thickness 2.1 cm.61 %of patients with histopathologically proven renal parenchymal disease have right kidney less than 10 cm. Echogenicity showed the strongest correlation with all four histologic parameters (r = 0.5–0.7). Renal parenchymal thickness was r weakly correlated with glomerular sclerosis (r = −0.32).By multivariate analysis, tubular atrophy, interstitial fibrosis, glomerular sclerosis and interstitial inflammation, all four histological findings were significant determinants of cortical echogenicity.
CONCLUSION: Cortical echogenicity is the sonographic parameter that correlates best with renal histopathology.
