Biodegradable nanoparticles for topical drug delivery into hair follicles

Penetration and delivery of drugs into deepest dermal layers is very limited. Several attempts were done in order to utilize nanoparticles for transdermal drug delivery but non to be used for topical delivery. There is an unmet need to develop efficient localized drug carriers with local effect to treat pathologies associated with the deep epidermal layer of the skin.

Here we present the development of unique biodegradable nanoparticle carriers which has the capacity to accumulate in the hair follicles and release drug topically.