Iodixanol Injectable Polymer as Contrast Agent - ICRS 2018 The 11th Meeting of The Israel Chapter of the Controlled Release Society

MAHRAN DAIFA Moran Haim Zada Arun Yuvuraj Eliel Ben David Nahum Goldberg Abraham J. Domb

Institute of Drug Research, School of Pharmacy-Faculty of Medicine and Hadassah Hospital, The Hebrew University of Jerusalem, Israel, Jerusalem, Israel

Injectable implants based on biodegradable polymers for local delivery of drugs allows the delivery of high and localized doses of drugs for prolonged period to the diseased tissue while minimizing systemic distribution causing adverse effects.

Biodegradable Poly(ester-anhydride) of ricinoleic acid and sebacic acid have been studied for controlled local drug delivery of antibiotics, anticancer agents and local anesthetics. In this study, we extended the use of this polymer to serve as a diagnostic marker in mammography. Iodixanol, an iodinated molecule commonly used as diagnostic contrast agent, was used in this study.

Poly(Sebacic acid-co-Ricinoleic Acid) pasty polymer loaded with Iodixanol encapsulated in PLGA75:25 particles and iron oxide was tested for its visibility by MRI, CT and Ultra Sound (US). Pasty formulation injected in mice was visible by MRI, CT and US for at least one month after injection. This formulation my replace the metallic clip currently in use for marking suspected tissue sites in the breast during mammography.