Comparative Clinical Trial of Two Remineralizing Treatments in Primary Molars

Background: Dental caries is a dynamic process, due to imbalance in the mechanism of remineralization that occurs naturally and continuously in the oral cavity. In recent years, the application of compounds based on fluoride and calcium has been promoted to prevent early childhood caries. However, it is important to have clinical evidence about its effectivenes.

Method: A clinical trial was carried out for six months on 151 children with different treatments; First group: Casein phosphopeptide amorphous calcium phosphate (CPP-ACP) weekly; second group: sodium fluoride varnish with tricalcium phosphate (NaF.TCP) every three months; Control group only brushed their teeth with fluoridated toohpaste, The evaluation was performed by an pediatric dentist with the International Caries Detection and Assessment System (ICDAS). Only healthy primary molars with incipient caries were included.

Results: After six months, when comparing the groups, the free caries surfaces treated, did not show differences between the different treatments: CPP-ACP (25%); Na-TPC group (31.8%) and control group (27%) respectively. The follow-up of the incipient lesions detected at the baseline stage showed remineralization in 37.5% of the surfaces of the CPP-ACP, 22.4% of Na-TPC) and 2.3% of the control group (p <0.01).

Conclusion: Both treatments were effective to prevent caries lesions, however CCP-ACP had better effectiveness for remineralizaton incipient caries lesions