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Multi-residue determination of 21 organic compounds in fish tissue using liquid chromatography-tandem mass spectrometry.
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1Kimron Veterinary Institute, Ministry of Agriculture, Rishon LeZion, Israel
2The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, Israel
2The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion, Israel
A rapid and sensitive multi-residue method for the determination of 21 organic contaminants belonging to different classes in fish tissue was developed and validated. The method involved a simple extraction step with acetonitrile followed by a cleanup step based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach. Analysis was performed in a single run by liquid chromatography coupled with electrospray ionization and tandem mass spectrometry (LC-ESI-MS/MS). The accuracy values for all of the analytes were between 80 and 117%; relative standard deviation values were in the range of 1-18 %. Limits of quantitation of the target compounds varied from 0.02 to 5ng/gr.
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