Autism Spectrum Disorder and Vitamin Deficiencies: a Case Series of 3 Pediatric Patients Presenting with Scurvy

Rana Swed-Tobia 1 Ahmad Haj 1 Daniella Militianu 2 Orly Eshach 3 Sarit Ravid 4 Ram Weiss 1 Yonatan Butbul Aviel 1,5
1Department of Pediatrics B, Ruth Rappaport Children's Hospital- Rambam Medical Center, Haifa, Israel
2Department of radiology, Ruth Rappaport Children's Hospital- Rambam Medical Center, Haifa, Israel
3Pediatric gastroenterology unit, Ruth Rappaport Children's Hospital- Rambam Medical Center, Haifa, Israel
4Pediatric Neurology unit, Ruth Rappaport Children's Hospital- Rambam Medical Center, Haifa, Israel
5Pediatric Rheumatology Service, Ruth Rappaport Children's Hospital- Rambam Medical Center, Haifa, Israel

Context: It has been recognized in number of studies that some children with autism spectrum disorder (ASD) have highly specific food selectivity and therefore are prone to nutritional deficiencies of different kinds.

Methods and main findings: We report three cases of patients with ASD, presenting with refusal to walk and gingivitis that underwent comprehensive evaluations before establishing the diagnosis of vitamin C deficiency (Scurvy) and subsequent resolution of symptoms after treatment with vitamin C.

Conclusions: Searching for vitamin deficiencies in children with ASD is essential and providing multivitamin supplementation whenever food selectivity is noted may prevent significant morbidity.

Key words: Autism spectrum disorder, Food selectivity, Scurvy, Vitamin C









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