Mean Platelet Volume and Clinical Outcomes of Patients with Chest Pain Discharged from Internal Medicine Wards - The 66th Annual Conference of the Israel Heart Society & The Israel Society of Cardiothoracic Surgery

GIL BEERI ¹ Guy Topaz ² Alon Y. Hershko ^3,5 Avi Leader ^4,5 Yona Kitay-Cohen ^2,5 David Pereg ^1,5

¹Department of Cardiology, Meir Medical Center
²Department of Internal Medicine C, Meir Medical Center
³Department of Internal Medicine B, Meir Medical Center
⁴Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center
⁵Sackler Faculty of Medicine, Tel-Aviv University

Currently there are no clinical scores for risk stratification of low-risk patients with chest pain. We aimed to examine the association between mean platelet volume (MPV) and risk for adverse clinical outcomes in patients with chest pain discharged from internal medicine wards following ACS rule-out.

Included were patients who were admitted to internal medicine wards and were discharged following an ACS-rule-out during 2010-2016. The primary endpoint was the composite of all-cause mortality and hospital admission due to ACS at 30-days following hospital discharge.

Included in the study were12,440 patients who were divided into 3 groups according to MPV. The composite endpoint of 30-day all-cause mortality and hospital admission for ACS occurred more frequently among patients with high MPV. Each 1 point increase in MPV was associated with an 18% increase in the risk for the composite endpoint (p=0.02).Considering patients with MPV8.8 fl) (HR 1.6, 95%CI=1.1-2.5, P=0.04). Each 1 point increase in MPV was associated with an 11% increase in the risk for 1-year all-cause mortality (p=0.01) and a 10% increase in the risk for 1-year ACS (p=0.04).

We found an independent association between high MPV and the risk of death and ACS among patients with chest pain who were discharged from internal medicine wards following an ACS-rule-out. MPV may be combined in the risk stratification of patients with chest pain.