Long Term Outcomes of Percutaneous Coronary Intervention for Unprotected Left Main Coronary Artery According to the SYNTAX Score

Background: SYNTAX is an angiographic score quantifying the extent and complexity of coronary artery disease. With technical improvements and growing operator experience percutaneous coronary intervention (PCI) of unprotected left main coronary artery (uLMCA) is becoming common practice.

Objective: to evaluate long term outcomes of uLMCA PCI according to SYNTAX score in a contemporary cohort.

Methods: this retrospective study included patients that underwent PCI of uLMCA throughout 2006-2018, in a tertiary hospital. Clinical parameters, PCI characteristics and follow-up data analyzed. Patients were classified into 3 groups according to the SYNTAX score: group 1: <22, group 2: 22-32, group 3:≥33 Clinical outcomes were 3-year MACE (death, unstable angina, myocardial infarction, stroke, stent thrombosis, urgent revascularization) and all-cause mortality.

Results: Overall 311 patients were abalyzed, mean age 74.7±11.9, males: 69%. Mean SYNTAX scores were: group 1 (n=91): 15±4.5, group 2 (n=136): 27.4±2.9, group 3 (n=84): 40.4±6.6, p

Conclusions: SYNTAX score is a useful predictor of long term outcomes in contemporary “real world” patients undergoing PCI of uLMCA.

Figure. 3-years mortality and MACE according to SYNTAX score