Early Discharge within 72 Hours following Acute Myocardial Infarction and Primary PCI is not Associated with Higher Mortality Rates or MACE (EDIPOS tRIAL)

Background: Current Guidelines recommend hospitalization of 2-3 days in ICU and additional days in Non-ICU units. In Selected low risk patients early discharged within 72 hours is reasonable. We assess the outcome of early discharge within 72 hours.

Method: We conducted a retrospective cohort study based on data from January 2012 to December 2015. Patients were classified into 3 Groups according to Length of hospitalization (LOH); 48 hours, 48-72 hours and more than 72 hours. Primary end points were; all-cause Mortality and Major Cardiovascular Events (MACE) within 30 days and 1 year. Secondary endpoint includes renal insufficiency.

Results: A total of 178 Patients included in the Study. 60 patients (33.7%) discharged within 48 hours (<48h), 75 pts (42.1%) discharged after 72 hours (>72h) and the remaining 43 (24.2%) discharged between 48 and 72 hours (48-72h). Pts discharged after 72 hours were significant Older (p<.001) and experienced greater myocardial damage (p <0.001) and a significant reduction in systolic function LV function (p <0.02). There was no significant difference in mortality rates (8.1%, 2.3% and 1.7%, 72, 48-72 and 48, respectively, p <.28) and the incidence of 30 days and 1 year MACE (p

Conclusion: Our study shows that very early discharge, within 72 hours, after acute Myocardial Infarction and Primary PCI is not associated with a significantly higher rate of mortality or MACE up to one year after discharge. Early discharge, within 72 Hours, in highly selective pts should be explored in a large prospective randomized trial.