Bone Health in Adolescents with Anorexia Nervosa: Comparison of Z score Bone Densitometry with Antropometry and Serum Leves of Osteocalcin and P1NP

We describe a group of 16 adolescents with anorexia nervosa (AN). We performed bone densitometry and examined serum levels of osteocalcin and N-terminal procollagen 1 (P1NP) peptide. Anthropometric data and a history of the disease were evaluated. The disease lasted for an average of 7.5 months, the age of adolescents was 14-16 years. Amenorea lasted 5-12 months, twice primary amenorrhea was present. The weight loss was 5-36 kg. Examination of sex hormones has produced findings that are consistent with central hypogonadism. Estradiol was 6 times below 18.4 pmol / L, LH was 5 times below 0.1 U / l. Densitometric examination yielded below average Z scores, in 4 girls the values ​​were below 2 sigma Z score. The most pronounced changes were in the Z score of the spine (mean -0,879), the mean Z-score of the femoral neck was -0,518, and the TOTAL Z score was - 0,66. Both osteocalcin and P1NP values were below average, with two girls achieving osteocalcin less than 2.5 percentile for a given age, and P1NP reached less than 2.5 percentile for a given age in four girls. We will monitor the densitometry ​​for 1 and 2 years after the first examination and compare it with serum osteocalcin and P1NP values and we will try to suggest a treatment scheme for secondary osteoporosis in adolescents with AN. The work is supported by a Thomayer hospital grant: MZd 2018 č.2 RVO-TN/2018: DZ 1816