Helicobacter Pylori Infection Associated with Henoch-Schonlein Purpura

Introduction: Henoch-Schonlein-purpura is a systemic vasculitis, of small vessels, resulting in skin, joint, gastrointestinal and renal involvement. The pathogenesis of HSP t is postulated that an unknown chronic antigenic stimulus, In children the prognosis is good, as HSP typically resolves rapidly and without complication. Helicobacter pylori is of the most common bacterial infections may cause some extra intestinal manifestations some of which are dermatological conditions, including Henoch-Schönlein purpura.

Case Report: A previously healthy 10year-child was admitted to our department , because of-week history of abdominal pain, and purpura on his lower extensor extremities. Physical examination revealed purpuric papules, on the legs, thighs, buttocks,. On admission, his temperature was 37.5°C, , and blood pressure 110/60 mmHg. showed a white blood cell count of 18200/mm³. The hemoglobin concentration was 11.8g/dL, the platelet count was 400000, while normal results for serum creatinine level Urinalysis revealed microscopic hematuria and proteinuria 200 mg/24 hrs). Occult blood was found in the feces., breath test for H. pylori showed a positive result. the patient received a two-week treatment course consisting of omepradex+, amoxicillin, and clarithromycin without steroid treatment. After the treatment, the abdominal manifestations dramatically subsided within three days and the purpuric skin lesions resolve.

Conclusion: H.pylori infection has been associated with certain extra-digestive dermatological conditions, including chronic urticaria, systemic sclerosis, and atopic dermatitis The symptoms of HSP disappeared after H. Pylori eradication therapy, In conclusion, H. pylori may be an etiological factor in pathogenesis of HSP and breath test fo H. pylori examination should be considered.