Analisys of Carbohydrate Disorders Changes in Children Born with Low, Very Low and Extremely Low Body Weight

Hypoglycemia is dangerous in the early neonatal period in that it contributes to the occurrence of intraventricular hemorrhage. In most cases, hypoglycemia in newborns is asymptomatic. The danger of hypoglycemia is that, generalized violation of metabolic processes, which further leads to neurological disorders. Hyperglycemia is more common than other metabolic disorders. In premature babies, it is detected in the neonatal period in 40-80%. The goal is to compare the frequency of carbohydrate metabolism disorders in premature newborns with different body weights during the rehabilitation stage. It is identified by the standard method and with the help of continuous monitoring of glycemia level.

Material and methods: 40 premature infants with low, very low and extremely low birth weight, born before 32 weeks of gestation (main group), and 20 premature newborns with gestation age of 34-37 weeks, comparable by sex and age, will be up to control groups. Glucose was analyzed using the glucose oxidase method using a Hitachi 912 analyzer and iPro2 continuous glucose monitoring system for 7 days (Medtronic MiniMed, Inc.). \

Results: The frequency of carbohydrate metabolism disorders according to the standard method in the examined was found in 18%, the glycemia range from 2.1 ± 1.1 to 19.0 ± 1.2 mmol / l. When analyzing the data obtained by the continuous monitoring system, violations were recorded in 40% of cases in the range of 1.9 - 22.0 mmol / l. In patients depending on birth weight, factors that increase the risk of life-threatening conditions, including death, LBGI (risk index for hypoglycemia) 8.04 in children with HMWT, HBGI (risk index for hyperglycemia) = 4 4 in children were identified with gmt.
Conclusions: Continuous glucose monitoring has great advantages compared with standard methods of glycemic control in preterm infants, which allows to get personalized results and predict life-threatening conditions.