Detection of Diabetic Autoantibodies for Obesity in Children and Adolescents.

Relevance: Obesity in childhood is an urgent problem of modern health care. Being overweight in children is a risk factor for developing type 2 diabetes. Children and adolescents with obesity should actively identify violations of carbohydrate metabolism, dyslipidemia, hypertension for the diagnosis of metabolic syndrome.

Objective: To investigate the presence of autoantibodies in children and adolescents with obesity as a predictor of carbohydrate metabolism disorders.

Materials and methods. Surveyed 20 children aged 8 to 18 years with a diagnostic criterion for obesity by SDS BMI> 2.0. Laboratory tests included biochemical blood tests, insulin levels, C-peptide, autoantibodies to β-cells (ICA), glutamate decarboxylase (GADA), tyrosine phosphatase (IA2A), insulin (IAA) and zinc transporter (ZnT8A).

Results: the burden of heredity in obesity and T2DM was in 76.4% of cases. The average age of children was 13.8 years (10; 18). The average BMI of SDS was 2.9 (1.9; 3.8). The insulin level was 28.3 µMU / ml (13.7; 36.6), the level of C-peptide was 3.9 ng / ml (2.1; 4.9). Diagnostically significant positive levels of ZnT8A ≥ 15 MU / ml, IÀ2A ≥ 10 MU / ml, IAA ≥ 10 MU / ml were registered at 17.6%, 17.6% and 11.7%, respectively. Antibodies are equally found in both boys and girls. GADA

Conclusion. The detection of diabetic immunological markers in obesity in children requires further study and observation to analyze the prognosis of the development of carbohydrate metabolism disorders and the choice of the optimal management tactics.