Roseoloviruses In Patients With Neurological Disorders
2Pediatric Infectious Diseases Department, Belarusian State Medical University, Belarus
3Infectious Diseases Department, Belarusian Medical Academy of Post-Graduate Education, Belarus
4Infectious Diseases Unit №5, City Children's Infectious Clinical Hospital, Belarus
Background: Recent studies indicate that HHV-6 and HHV-7 may trigger some neurological disorders.
Methods: We detected HHV-6 and HHV-7 in 121 samples of clinical material (serum, peripheral blood cells, urine, saliva/buccal swabs, and CSF) from 31 patients with the following clinical diagnoses: encephalitis/meningoencephalitis, febrile seizures, epilepsy, children with unspecified febrile fever, psychotic disorders, chronic fatigue syndrome.Qualitative detection of HHV-6 DNA was carried out by real-time PCR with a commercial kit, and HHV-7 primers and probe (Wada et al., 2009) were used for detection of HHV-7 DNA.
Results: HHV-6 DNA was found in 6.45% patients (2 of 31): in saliva, cells and urine (n=1), in cells and serum (n=1). HHV-7 DNA we detected in 12.9% patients (4 of 31): in CSF with blood (n=1), in saliva and urine (n=1), in cells and saliva (n=1), in cells and CSF (n=1). Both HHV-6 and HHV-7 were found in 25.8% patients (8 of 31): 3 of them had both viruses in saliva, 1 – in blood cells; in other 4 children roseoloviruses were detected in variants – HHV-6+HHV-7 in saliva and HHV-7 in blood cells, HHV-6 in saliva and HHV-7 in cells, HHV-6 in urine and HHV-6+HHV-7 in buccal swabs, HHV-6+HHV-7 in saliva and HHV-7 in CSF and urine.The quantity of HHV-6 in urine was
Conclusion: Roseoloviruses are often detected in the clinical material of patients with neurological disorders. This can’t indicate its etiopathogenic role, since persistent carriage of latent roseoloviruses occurs in healthy controls. This requires further research.
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