Saudi Female with Successful Arrest of Progressive Juvenile Localized Scleroderma Using Interleuken-6 Antagonist

Juvenile localized Scleroderma is one of the pediatric rheumatological disorders that primarily affect the skin and subcutaneous tissue beside the other type which is systemic sclerosis as it is rare in pediatric population . Management of such diseases is really crucial as its significantly effects the health and the life quality of the children. Data shows the effectiveness of systemic corticosteroids in association with methotrexate (MTX) in patients with active JLS especially in progressive linear scleroderma and generalized or pansclerotic morphoea. If MTX is ineffective or the disease relapses after a period of clinical remission or in the case of MTX-intolerance mycophenolate mofetil (MMF) may be used despite the lack of good evidence in the literature. Few studies shows that using of tocilizumab is safe, well tolerated and may have therapeutic benefit in the cases with severe and refractory JLS. In this case which is first time reported in Saudi Arabia describing the response and the efficacy of Intereuken-6 Antagonist in JLS .