Ezh2 regulates early stages of T-helper cell differentiation

Following their first interaction with the antigen, naive T-helper (Th; CD4⁺) cells can differentiate into distinct effector and regulatory lineages characterized by specific profile of cytokines. These cytokines instruct eventually the strategy of the immune response. Previous studies in our lab showed that the polycomb group (PcG) proteins function in Th cells as both negative and positive transcriptional regulators. Our current study delineates a model in which Ezh2 dynamically modulates nuclear actin in a developmental- and lineage-specific manner.