Surgical operations are routinely utilized in order to fix dentofacial anomalies, improve dental arches and facial esthetics, and rehabilitate all jaw and tooth functions. The main objective in all surgical fields is to cause less tissue damage, thus decrease the number of potential complications and provide a less painful and more comfortable postoperative period for the patients. Piezoelectric surgery is a new technique that uses piezoelectric ultrasonic vibrations in order to perform safe and effective osteotomies and minimizes tissue damage and patient morbidity. After piezoelectric surgery edema, neurosensory dysfunction and pain levels were found to be lesser than conventional techniques. Patient satisfaction was found to be higher in piezoelectric surgery patients. The selective cutting ability of the piezoelectric surgery device provides an extremely safe osteotomy for patients by performing a selective osteotomy, thus preserving critical adjacent soft tissues. In this presentation clinical applications in association with scientific evidence will be presented.