Gene Polymorphism of Aspirin-induced Urticaria in Children with Kawasaki Disease

Objective: To investigate the distribution of the leukotriene synthase (LTC4S) A-444C gene polymorphism in children with Kawasaki disease in northern China and determine whether LTC4S A–444C is associated with AIU.

Methods: The clinical data of children with Kawasaki disease who were hospitalized in the Department of Cardiology, Children`s Hospital Affiliated with the Capital Institute of Pediatrics from April 2015 to November 2017 were collected, and the LTC4S A-444C gene polymorphism was detected to analyze the relationship between the LTC4S A-444C gene polymorphism and AIU. Results: A total of 574 children with Kawasaki disease were enrolled in the study. 1) The frequency of the A allele was 980 (85.4%), and the frequency of the C allele was 168 (14.6%). 2) Of the 417 patients with the AA genotype, 25 had urticaria, resulting in a positive rate of 6%. Of the 146 patients with the AC genotype, 11 had urticaria, resulting in a positive rate of 7.5%. Eleven patients had the CC genotype, 2 of which had urticaria, resulting in a positive rate of 18.2%. There was no significant difference among the three groups (P > 0.05).

Conclusion: LTC4S A-444C gene polymorphism exists in children with Kawasaki disease in northern China, but there is no correlation between LTC4S A-444C gene polymorphism and AIU.