Circulating tissue specific RNA and the link to general and pregnancy metabolism

Understanding human metabolism requires us to perform measurements directly with humans. Non-invasive cell free RNA measurements of tissue specific origin such as the placenta and pancreas can serve to inform the roles these organs play during periods of large metabolic changes. In our pilot studies, we explored the utility of these tissue specific cfRNA measurements in two metabolic scenarios : clinical cases of bariatric surgery and maternal metabolism during pregnancy.