We present a 7-year old healthy girl with traumatic proximal humeral fracture which failed conservative treatment. MRI was pursued and demonstrated aggressive features in favor of sarcoma. Biopsy samples revealed gram-negative rods with no evidence of malignancy consistent with an aggressive salmonella infection. Salmonella osteomyelitis is a rare entity, especially in healthy children, that carries clinical, laboratory, and radiographic similarities with bone sarcoma. Differential diagnosis, as well as clinical and radiographical pearls and pitfalls, will be discussed.
