DNA methylation: Bridging the gap between genes and function

The human genome contains all of the information needed for constructing every part of the body and for ensuring proper function. In addition to the basic sequence text, there is also a system of gene annotation that instructs cells when and how to use this information and this epigenetic control is usually mediated by DNA methylation. In order to decipher this process, we have studied how methylation patterns are established and maintained during development and deciphered how this influences gene function both in health and in diseases such as cancer. New experiments are beginning to reveal how DNA methylation may play a role in mediating changes in cell function as a result of environmental factors and aging, opening up new vistas in our understanding of how the body adapts to its surroundings.