GD is a genetic lysosomal storage disorder, found mainly in Ashkenazi Jews, involving several organs, leading to enlargement of spleen and liver, causing organ damage and fibrosis. SWE is a noninvasive, ultrasound based imaging technique which can accurately quantify the degree and severity of tissue fibrosis. Accepted biomarkers of disease severity and fibrosis were compared to liver and spleen SWE. The study hypothesis was that a direct correlation of SWE findings with severity of disease biomarkers exists. A direct correlation may promote early detection of organ damage and fibrosis with the use of SWE, thereby impacting on treatment planning and outcome.