Investigate the Effects of Deksametazon - 21 Disodium Phosphate on Edema, Pain and Trismus after Lower Impacted Third Molar Surgery

The physiological response of the body tissues to injury of any cause is inflam- mation and pain, which vary for each patient. After every surgical intervention, inflammatory mediators (prostaglandins, leukotrienes, bradykinin, platelet activat- ing factor, etc.) are released into the tissues in response to this irritation, with a subsequent increase in vascular dilatation and permeability, causing oedema and enhancing the interstitial tissue response. Surgical removal of the mandibular third molars is the most common surgical procedure in oral and maxillofacial surgery. The aim of this study was to compare the efficacy of three different routes of administration of deksametazon on pain, edema and trismus after impacted lower third molar surgery.

Double-sided symmetrical, lower impacted 3.molar indicated for extraction .(18-45 years) patients were randomly divided into 3 groups. İn each group 12 patients were examined. Dexamethasone 21-phosphate disodium drug was administered in anatomical regions designated as one-sided in each group (submokazal, masseter muscle, masseter muscle+ submokazal). The drug has not been applied to the other side. İn order to ensure standardization the operation was made by the same surgeon using the same technique.

In our study, statistically significant difference was found between test and control groups. There was no significant statistical difference between test groups. Submokazal + masseter muscle groups in compared to other test groups significant reduction in pain, edema and trismus was found but statistically no signifikant differences were found.

Keywords: Deksametazon- 21 disodium phosphate, impacted wisdom, edema