Ceretrieve is Developing a Unique Neurothrombectomy System with Integrated Embolic Protection to Improve the Ischemic Stroke Treatment and Clinical Outcomes

Despite technological advances with current thrombectomy devices, physicians are forced to choose between deploying expensive, cumbersome stent retrievers distal to the clot, thereby increasing the risk of distal embolization; or a quicker approach that involves inserting an aspiration catheter that has limited ability to provide efficient aspiration and increases the risk of distal embolization.

Clot fragments and embolization can worsen the existent stroke and cause new strokes to previously un-involved territories resulting in increased disability.

Ceretrieve`s next-generation aspiration catheter system removes all clot types in the brain, from first pass attempt and prevent distal embolization in a simple and rapid procedure:

(1) Navigate the device proximal to the clot. (2) Deploy large funnel- expands to vessel diameter to block blood flow. (3) Aspirate clot- inner diameter enlarges, aspirates entire clot (4) Close funnel tip (prevents releasing fragments or losing clot) and extract.

Ceretrieve has successfully tested system in animal, and shown superior performances when tested at the New England Center for Stroke Research, University of Massachusetts medical school. Mechanical thrombectomy was performed in a circle of Willis silicone vascular replica and circulating flow loop to mimic the physiological parameters of flow and pressure in the brain. Different clot models (soft, medium, hard) were used to form the MCA occlusion. All clot types were fully aspirated from first attempt into the deployed funnel, no distal emboli were visually observed.

Experienced team managing and leading the company and product development:

Maysa Mustafa, CEO: Biomedical Engineer, MBA; 14+ years in leading medical device development.

Dr. Ronen Jaffe, Cofounder: Cardiologist, Carmel Medical Center, Haifa.

Prof. Raul Nogueira, MD, Scientific Advisor: Prof. of Neurology, Neurosurgery and Radiology Emory University School of Medicine. Atlanta, GA; principal investigator DAWN study

Boris Degtiar, Engineering Manager: Mechanical Engineer, 20+ years’ experience in medical devices development and establishing manufacturing lines.