Spinal cord injury (SCI) disrupts signals between the brain and the body. In traumatic SCI, the primary impact damages cells and initiates a complex secondary injury cascade, which cyclically produces the death of neurons and glial cells, leading to ischemia and inflammation. In our approach, a small piece of fatty tissue biopsy is extracted from patients and the cellular and a-cellular materials are separated. While the cells are reprogrammed to become iPSCs, the extracellular matrix is processed to become a personalized hydrogel. Here, after mixture of the cells and the hydrogel, efficient differentiation into spinal cord motor-neuronal networks was performed to engineer patient-specific spinal cord implants. The implants were characterized for morphology and function and then transplanted into injured mice. Histologically, implant treated mice exhibited reduced inflammation and glial scar formation alongside high axonal recovery in the lesion area. Moreover, quantitative behavioral assessments were performed using catwalk system for gait analysis. The degree of inter-limb coordination during the gait cycle, measured by the regulatory index, was significantly improved in implant treated mice.