Morphology-Driven High-Plex Spatial Analysis of Tissue Microenvironments with the GeoMx™ Digital Spatial Profiling

Historically, immunohistochemistry and immunofluorescence have been used to assess spatial heterogeneity of proteins and nucleic acids in tissue specimens. However, these techniques are of limited utility due to restricted dynamic range, difficult quantification and limited multiplexing capability.

NanoString’s GeoMx™ Digital Spatial Profiling (DSP) is a novel, non-destructive, highly multiplexed assay for the digital characterization of protein and RNA expression from spatially discrete regions of interest (ROI) in FFPE tissue sections. GeoMx™ DSP can simultaneously quantify 96 protein targets and 1,000s of transcripts in multiple ROI and for up to 20 slides per day. Current applications include biomarker discovery, mechanism of action studies, and rare cell characterization.