Computational design of multispecific drugs for treatment of complex diseases

We present an approach for the design of Multibodies, human antibodies that can manipulate more than one pathway by specifically binding functional epitopes on multiple targets. Currently, most of the clinical trials that address complex diseases explore combination therapies: using multiple molecules together to attack more than one target. However, combination therapies present tremendous challenges, including the need to clinically study each molecule alone before exploring the effect of the combination. This exacerbates development and hinders the study of truly synergistic combinations that may be toxic or ineffective on their own. Computationally designed multibodies may overcome many of these challenges and allow for the execution of novel and sophisticated molecular strategies