Amyloid beta (Aβ) is a peptide that aggregates in the brain causing Alzheimer disease (AD). Amylin is a peptide associated with Type 2 Diabetes (T2D). Amylin peptides aggregate in the pancreas and consequently causing to death of β-cells. Histochemical studies showed that Amylin aggregates were found to be co-localized with Aβ aggregates to form the Amylin-Aβ aggregates in the AD patients’ brains. Therefore, it was proposed that T2D patients have more the risk to develop AD. Insulin is a hormone secreted from pancreatic β-cells together with amylin. Clinical studies showed that Insulin inhibit separately Aβ aggregation and Amylin aggregation. In order to provide insights into the effect of Insulin on Amylin-Aβ aggregates, molecular modeling tools are applied in the current project. Inhibition to the formation of these aggregates will assist to preventing T2D patients to develop AD.