Engineering gene expression based on the design of RNA folding and RNA-RNA interactions

Various studies from the recent years have demonstrated that local structures in the mRNA or pre-mRNA and RNA-RNA interactions can regulate gene expression in various ways. These novel regulatory rules can be used for engineering the gene expression of cellular and viral genes, providing a novel set of synthetic biology tools.

In this talk, I will show how such regulatory rules can be deciphered based on novel computational models and algorithms. I will also review some new discovered rules and will demonstrate their applications in synthetic biology.