ABSTRACT BY SPONSOR: A revolution in spatial biomarker discovery. Morphology-driven profiling with unlimited multiplexing of proteins and RNA by GeoMx™ DSP

Historically, immunohistochemistry and immunofluorescence have been used to assess the spatial heterogeneity of proteins and RNA in tissue specimens. However, these techniques are of limited utility due to restricted dynamic range, difficult quantification and limited multiplexing capability.

NanoString’s GeoMx™ Digital Spatial Profiling (DSP) is a novel highly multiplexed approach to characterize the spatial distribution and abundance of proteins and RNA from spatially discrete regions of interest (ROI) in FFPE tissue sections. To date, DSP analysis of 1,000s of proteins and RNA from patient samples across multiple tumor types and neurological diseases has revealed novel spatial biomarker signatures predictive of therapeutic response. Current DSP applications include biomarker discovery, mechanism of action studies, and rare cell characterization.