רמת IGE כללי בסרום כגורם מנבא של תגובה לטיפול בפוטותרפיה במטופלים עם דרמטיטיס אטופית

Atopic dermatitis (AD) is the most common chronic, inflammatory skin disease and it affects about 25% of all individuals at some point during their lifetime. Atopy is defined as the tendency to produce antibodies towards Immunoglobulin E (IgE) in response to common environmental proteins. Even though IgE levels are not elevated in all AD patients, total serum IgE levels have been reported to be associated with the severity of AD in several reports during the years. Phototherapy is a second-line treatment for moderate to severe AD which successfully eases cutaneous inflammation.

This study is aimed to assess whether total serum IgE levels correlate with the response to phototherapy treatment in AD patients, and can therefore be considered as a reliable biomarker that could guide patient management.

We evaluated 96 AD patients that were treated in the phototherapy unit at the Sheba Medical Center for: demographic characteristics, IgE levels, hospitalization length and their requirement for systemic treatment. IgE level has demonstrated significant predictive values (p<0.001) and could therefore be proposed as a selection criterion for patient suitability for phototherapy treatment.