Effect of Autoimmune Inflammatory Process on the Development of Anemic Sindrome in Children with Diffuse Connective Tissue Disease

The study was conducted to study the process of autoimmune inflammation in children with diffuse connective tissue diseases, iron metabolism, the development of anemic syndrome.32 sick children aged 3-18 with diffuse connective tissue disease were involved in the examination. Each of these children underwent a complete blood count, iron, ferritin, transferrin, transferrin saturation, folic acid, vitamin B₁₂,CRP,RF,ASO,erythropoietin, direct Coombs reaction,ANA,anti-ds DNA, anti-ss DNA. The obtained results were processed in Microsoft Office Excel-2010, SPSS-20 statistical packages by variation (U-Wilcoxon and discriminant ( χ2-Pearson) analysis methods.As a result of the study, 20 (62.5%) of the 32 children examined were diagnosed with anemic syndrome, of which 17 were girls (85 %) and 3 were boys (15%). The principles of randomization in gender indicators were followed in the groups.As a result of the study, it was determined that there is a correlation between the laboratory indicators of anemia and the indicators of clinical and laboratory activity of the underlying disease. The autoimmine marker found that there was a positive feedback interaction between anti-ssDNA and Hb, p=-0,22, p<0,05, and a positive correlation between CRP and ANA (r= +0,55, p<0,01).There was also a clear correlation between CRP and hemoglobin. Correct feedback interaction between CRP and Hb before treatment r= - 0,22 and after treatment r= -0,27,(p<0,05),between CRP and ferritin before treatment -r=+0,29,(p<0,05) and after treatment r=+0,33 (p<0,01) was found to have a positive interaction.After baseline therapy of the underlying disease, Hb levels increased by 14,2% (p<0,001) in patients with anemic syndrome, serum iron increased by 51% (p<0,001), ferritin levels decreased by 20,4% (p<0,05) and TFD% increased by 21,1%(p<0,001).It has been studied that chronic autoimmune inflammatory process during promotes the development of anemic syndrome and worsens the course and prognosis of the underlying diffuse connective tissue diseases.