Association of Gall Bladder Disease and Coeliac Disease

Introduction: Gall bladder disease or malfunction can be associated with coeliac in children. It can cause pain in the upper right quadrant of the abdomen or it can be incidental finding on routine ultrasound.

Aims and Objective: to create awareness regarding association of gall bladdder disease and coeliac disease in children.

Material and methods: we diagnosed 23 cases of coeliac disease with help of tissue transglutaminase antibodies as screening test in children having a triad of anaemia, failure to thrive and bowel disturbance and confirmation by anti endomysial antibodies and gut biopsy. Routine work up also included abdominal ultrasound.

Results: out of 23 cases,4 have gall bladder stones.Out of 4, 2 were solitary and 2 were having multiple calculi.Only one patient was having pain in right upper quadrant of the abdomen and in rest 3 it was an incidental finding.

Conclusion: CCK(Cholecystokinin) is the harmone responsible for gall bladder contraction.The bulk of this harmone is produced in duodenum. Active coeliac disease can cause a reduction of duodenal production of CCK. This can abnormally decreased gall bladder contraction in coeliac patients resulting in stone production. So it is the result of decreased producton of endogenous production of CCK and not a lack of end organ responsiveness.