Real Life Study on Natural Combination Spray for Children with Allergic Rhinitis

Zorica Zivkovic ^1,2 Katarina Milosevic ^3,4 Lidija Sagic ⁵ Olivera Ostojic ⁶ A Djuretic ⁷ Gordana Kostic ^8,9 Snezana Zivanovic ^10,11

¹Children’s Hospital for Lung Diseases and Tuberculosis,, Medical Center “Dr Dragisa Misovic”, Belgrade, Serbia, Belgrade, Serbia
²Business Academy, Faculty of Pharmacy Novi Sad, Novi Sad, Serbia
³Pulmonology Department, University Children`s Hospital Belgrade, Serbia, Belgrade, Serbia
⁴School of Medicine, University of Belgrade, Belgrade, Serbia
⁵Pulmonology Service, Municipal Institute for Lung Diseases and Tuberculosis Belgrade, Serbia, Belgrade, Serbia
⁶Children's Hospital for Lung Diseases and Tb, Medical Center "Dr Dragisa Misovic", Belgrade, Serbia
⁷Pediatric Clinic, Institute for Children and Youth Health Care of Vojvodina, Novi Sad, Serbia
⁸Pediatric Clinic, Clinical Center of Kragujevac, Kragujevac, Serbia
⁹School of Medicine, University of Kragujevac, Kragujevac, Serbia
¹⁰Pediatric Clinic, Clinical Center of Nis, Nis, Serbia
¹¹School of Medicine, University of Nis, Nis, Serbia

Symptoms of allergic rhinitis (AR) in children are fly like and attributable to acute upper airways infections. Due to its nonspecific clinical feature, misdiagnosis and overtreatment the AR attract great professional attention and public awareness as well. Despite appropriate number and quality of anti allergic medicines need for additional products, natural and symptoms relievers is evident. The main goal of this study was to evaluate the efficacy and safety of natural combination spray for allergic rhinitis in children. The real life study enrolled 237 children, age range 3 to 18 years. At study entry demographic data and detailed clinical history were collected. At the initial visit children were given nasal anti allergic spay (PropoMucil®, combination of standardized propolis with 12% of polyphenol and N-acetylcysteine, quercetin, thyme and eucalyptus essential oil and vitamin D3 and E, Abela Pharm, Belgrade, Serbia) . The second visit after 30 days consisted of clinical symptoms evaluation and questionnaire about efficiency (visual analog scale instrument). At the beginning most of the parents reported nasal obstruction (90% of children), nasal itching ( 69%) .Persistent moderate to severe AR was detected in 58% of children.No treatment previously was reported in 3% of children, while rest of the children were given all sorts of anti allergic drugs.with variable efficiency. After 30 days and usage of PropoMucil® allergy nasal spray, clearly the good efficacy and clinical improvement were revealed. Nasal itchiness improved significantly (severe symptom in 69,2% at the begining , only 17,7% at the end period, p< 0.001). Nasal obstruction was present in 89,9% at the begining and reduced to 31,6% at the end, p< 0.001). The combination propolis, N-acetylcysteine, quercetin, thyme and eucalyptus essential oil and vitamin D3 and E in nasal spray was proven a good choice for the treatment of allergic rhinitis in children.