Impaired Kidney Function in Adolescents with Eating Disorders
2Dietary Services, Schneider Children's Medical Center of Israel
3Psychologic Medicine, Schneider Children's Medical Center of Israel
Background: Anorexia nervosa (AN) is a common psychiatric disorder associated with high morbidity and mortality. Impaired kidney function (IKF) in AN has been described but its incidence and correlation with disease severity are unknown.
Methods: Retrospective computerized charts review of patients hospitalized at SCMCI between 2010-2019 with a recent diagnosis of AN was performed, to obtain data about serum creatinine (SCr), BMI and physiologic parameters of AN severity. Estimated glomerular filtration rate (eGFR) and SCr/BMI ratio were calculated, the latter to overcome possible IKF underestimation.
Results: 397 patients were included (81.6% females, age: 14.6±2.2 years, median BMI percentile: 12.3, IQR: 0.9-42). min-eGFR was not in complete correlation with SCr/BMI (R2 =0.44). IKF (min-eGFR
Conclusion: IKF in patients with AN is common and worsens during hospitalization. IKF patients had lower minHR and FT3 and longer hospitalization, without differences in admission BMI. Therefore, IKF may be a better marker of AN severity.