Background: Influenza virus infections are a major cause of morbidity in children, including neurologic complications.
Aim: To assess the demographic characteristics, clinical course and outcome of children with Influenza virus infections, comparing episodes with and without neurologic complications (neuro-Flu and other-Flu, respectively).
Methods: A retrospective, cohort study of hospitalized children
Results: Of overall 951 children, 250 had neuro-Flu (26.2%). The most common neurologic presentation was seizures (n=125, 13.1%), followed by headaches (n=49, 5.2%), irritability/apathy (n=18, 1.9%), positive meningeal signs (n=9, 0.9%), and symptoms presented in
Children with neuro-Flu were older than other-Flu (mean age ± SD 62±55 vs. 44±47 months; p<0.001), with significantly higher rates of males (62.0% vs. 53.7%), Jewish ethnicity (45.7% vs. 33.5%), and previous neurologic conditions (11.4% vs. 5.8%). In contrast, neuro-Flu had lower rates of cardiac/respiratory background illness (4.4% vs. 11.7%). Rates of fever were similar in the two groups (>90%), as well as the proportions of influenza type A (both 82-84%). Lymphopenia was more common in neuro-Flu (52.7% vs. 43.8%). Outcome measures, including intensive care unit admission (2.5%) and mortality (0.9%), were similar comparing the groups.
Comparing episodes with seizures with other-Flu, Jewish ethnicity, neurologic background illness and lymphopenia were more common in children with seizures.
Conclusions: neurologic complications in influenza are associated with older age, ethnicity, neurologic background illness & lymphopenia.