Exosomes derived from mesenchymal stem cells improved core symptoms of mouse models of Autism

Autism Spectrum disorder (ASD) is a neurodevelopmental disorder, mainly characterized by impairment of social interaction, communication deficits, and restricted interests. Currently, there is no pharmacologic medication that can reverse ASD symptoms. Using Shank3 InsG3680 mouse model of autism, mutation that present in 1% of ASD, we show that intranasal administration of exosomes derived from adipose mesenchymal stem cells has a remarkable ability to improve autistic-like behaviors. The treatment shows significant improvement in social interaction, communication, and risk assessment that preserved six months after single intranasal administration. Thus, our results suggest that non-invasive exosomes treatment might be used for ameliorating autistic-like phenotypes in patients.