No Correlation Between Diffuse Idiopathic Skeletal Hyperostosis and Coronary Artery Disease Using Two Different Scoring Systems
2The Leviev Heart Center, Sheba Medical Center, Israel
Purpose: to investigate the association between DISH and coronary artery disease (CAD) as measured with the coronary artery calcification score (CACS) and CAD-Reporting and Data System (CAD-RADS) score in a cohort of symptomatic chest pain patients.
Methods: Consecutive cardiac CT scans performed before and after IV contrast administration were evaluated for CACS (Agatston method), CAD-RADs and the presence of DISH. Association of DISH with the presence and extent of CACS/CAD-RAD scores were analyzed with and without adjustment for known atherosclerotic risk factors.
Results: The study cohort included 268 subjects ( M/F:157/111, median age: 54 years). DISH was present in 24.3% (65) of subjects. CACS was significantly higher in the DISH group compared to the non-DISH group in the univariate analysis (median CACS DISH=2 [0-80.5] vs. median CACS non-DISH=0 [0-11], p<0.005) but this association did not persist on multivariate analysis. There was a positive trend toward higher CAD-RAD scores in the DISH group (p=0.03) but after adjustment for age, male gender and family history, this tendency was not significant.
Conclusions: No correlation was found between the presence of DISH and CACS and CADRAD scores. Our findings suggest a more complex and possibly non-causal relationship between coronary artery disease and DISH.