ISRA May 2022

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) In A Patient During the Post-COVID-19 Period: A Case Report

Amir Haddad 1,3 Nizar Horrany 2,3 Boshra Nasser 1,3 Michael Jerdev 1,3
1Medical Imaging, The Baruch Padeh Medical Center, Israel
2Stroke Unit, The Baruch Padeh Medical Center, Israel
3Azrieli Faculty of Medicine, Bar-Ilan University, Israel

Myelin oligodendrocyte glycoprotein​ antibody-associated disease (MOGAD) is a group of inflammatory demyelinating disorders, predominantly affecting the optic nerves and spinal cord. A variety of CNS manifestations of COVID-19 infections has been reported and it has been stated that viral infections can take part in the development of inflammatory demyelinating diseases, including MOGAD. Here we report, a case of optic neuritis (ON) and longitudinally extensive myelitis associated with myelin oligodendrocyte glycoprotein (MOG) antibody in 24-year-old male four months after infection by COVID-19. This case highlights a possible causal association between inflammation due to COVID-19 and activation of MOG-IgG associated disease.