High Correlation between Maternal and Infants Sars-cov2 Antibodies after Immunization during Pregnancy
2Emergency Department, Schneider Children Medical Center in Israel, ישראל
3Medical school, Ariel University, ישראל
Background: The characteristics of infantile serum antibodies born to mothers vaccinated with BNT162b2 mRNA vaccine during pregnancy are not well understood, and the potential protection from SARS- CoV -2 in the first months of life remains undetermined.
Aim: We aimed to investigate the IgG presence in serum of infants up to 3 months of age, to mothers who were vaccinated with the BNT162b2 mRNA vaccine during pregnancy and were not infected with SARS- CoV -2.
Methods: We analyzed serum antibodies (TrimericS IgG and Anti Nucleotide) of 31 infants up to 3 months of age and 23 matching mothers- vaccinated with 2 doses of BNT162b2 mRNA vaccine during pregnancy.
Results: 29 infants (93.5%) in all age groups showed positive IgG SARS-CoV-2 TrimericS IgG. Strong correlation is shown between mothers and infants antibodies levels (ρs = 0.814; P < .001). Anti- S levels increase as the gestation age at time of first vaccine dose is higher, and decreases as time passes from the first vaccine (respectively ρs = 0.568; P = .00104, ρs = 0.616; P < .001). The infant - mother antibodies ratio decreases as the infant is older (ρs = 0.72; P < .001)
Conclusion: Infants up to 3 months of age have shown presence of IgG antibodies for spike protein in the serum. Antibody levels are highly correlated with the mother’s level of serum antibodies, the ratio between infant and mother sera levels decreases as the infant’s age is older.