The Association Between Time in Range %, Measured by Continuous Glucose Monitoring (GCM) and Physical & Functional Indices Amongst Older People with Type 2 Diabetes
2"Blumental" physical Therapy Clinic, Clalit Health Services
3Endocrinology & Diabetes Service for Women and in Pregnancy Division of Endocrinology, Diabetes and Metabolism, Sheba medical center
4Herczeg Institute on Aging, Tel-Aviv University
5Physiotherapy, Ariel University
Older people with diabetes have an increased risk for mobility disability and sarcopenia. Studies show an association between A1C and Sarcopenia. Less is regardknown ing the relationship with Time In Range (TIR).
Aims:
To assess among older people with diabetes type 2, the association between: TIR and aerobic capacity, gait speed, strength, balance, and frailty indices.
Methods:
A cross sectional study, in people with diabetes > 60Y. Participants were provided with a blinded CGM system- (iPro™ professional CGM, Medtronic) for 1 week and underwent physical-functional assessment at two time points. The association between the % of time in range (TIR) and several physical indices was determined using linear regression.
Results:
This analysis pertains to 144 men and women.
After adjustment for age and gender, a 1% higher TIR (70-180) was associated with a 0.169 higher score on the 6-minute walk score (aerobic capacity and endurance) (P-value=0.023), 0.119 higher score on the Grip test (upper limb muscle strength (P-value=0.039)), 0.164 lower score on the 360-turn test (dynamic balance) (P-value= 0.039) and 0.165 lower score on the Timed Up & Go(TUG), (fall risk and balance) (P-value=0.037).
Conclusion:
Higher % TIR is associated with better scores on indices of muscle strength, aerobic capacity, and balance. Future studies are needed in order to elucidated if glucose levels are merely a marker of disease severity, or if there is possibly a causal relationship.
