Insulin Degrading Enzyme (IDE) and Physical Function in Elderly Adults with Diabetes Mellitus
2Sackler Faculty of Medicine, Tel Aviv University
3Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, the George S. Wise Faculty of Life Sciences, Tel Aviv University
4Sagol School of Neuroscience, Tel Aviv University
5Institute of Endocrinology, Metabolism and Hypertension and the Sagol Center for Epigenetics of Metabolism and Aging, Tel Aviv Sourasky Medical Center
6Department of Internal Medicine A, Shamir (Assaf Harofeh) Medical Center
7The Shmunis School of Biomedicine and Cancer Research, the George S. Wise Faculty of Life Sciences, Tel Aviv University
Background:
IDE was suggested to play an important role in maintaining blood insulin levels. Sofer et al 2021 suggests a correlation between elevated levels IDE in the serum of metabolic syndrome, pre diabetes, to C peptide .
Aim:
To examine the association between serum IDE levels and physical indices in elderly adults with diabetes mellitus type 2 (DM2).
Methods:
A cross sectional study that included 91 individuals with diabetes over the age of 60. Demographics, medical history were collected. In addition, participants underwent assessment of physical capacity using validated tests of aerobic, balance and strength capacity conducted by a licensed physiotherapist. Serum IDE levels were determined using a highly sensitive ELISA. Participants were divided into above and below median IDE level and the difference in study variables distribution between the two groups was determined using the Mann-Whitney test.
Results:
Those with IDE levels above and below the median IDE levels did not differ significantly in age, gender, diabetes duration, diabetes complications, dyslipidemia or hypertension prevalence, A1c% or insulin usage. Those with IDE levels above the 50th percentile exhibited better performance in a variety of physical function tests including the 6-minute walking test (513 vs 458 meter; P=0.012), 30 seconds chair stand (14.5 vs 14; P=0.005) and grip strength (32 vs 25 kg; P=0.026).
Conclusions:
Higher IDE levels in patients were associated with better performance in physical capacity tests. This may suggest that IDE may represent an important marker for insulin activity to follow during disease progression.
