Building Brain Cellular Complexity Using Stem-Cell Based Technology
Medical Neurobiology, Faculty of Medicine-Hebrew University of Jerusalem, Israel
Due to the immense complexity of the human brain, the study of its development, function, and dysfunction during health and disease has proven to be challenging. The advent of patient-derived human induced pluripotent stem cells, and subsequently their self-organization into three-dimensional (3D) brain organoids, which mimics the complexity of the brain`s architecture and function, offers an unprecedented opportunity to model human brain development and disease in new ways. However, most of these models lack essential cellular components of the human nervous system, such as neurovascular and neuroimmune cells. I will discuss our recent progress to overcome these issues.