Reliable Fluorescent Extracellular Vesicles Standard

Extracellular Vesicles (EVs) are an excellent tissue source for non-invasive biopsy. It has been proven to hold biomarker information that can be used as a fingerprint for disease detection. New research tools are essential to turning the collected data into quantitative signal. Thus, In collaboration with the lab of prof Hendrix from the Ghent university, Ghent, Belgium, We have developed recombinant exosome standards which express green fluorescent protein (GFP) on their membrane surface (product SAE0193) and enable sensitive and differential trackability of EVs. These recombinant exosome standards EVs share equivalent physicochemical and biochemical properties to sample EVs and are suitable for use as biological reference material with EV separation methods and measurement instrument. Thus it is aimed to serve as standards for quality control, data normalization, method development, and optical and non-optical EV calibration measurements.