ASSOCIATION OF GENETIC MARKERS WITH INFERTILITY IN WOMEN UNDERGOING BARIATRIC SURGERY - COGI 2023 The 31st World Congress on Controversies in Obstetrics, Gynecology & Infertility

Charalampos Voros ¹ Despoina Mavrogianni ¹ Kyriakos Mpananis ⁵ Tereza Vrantza ² Konstantinos Albanopoulos ³ Evangelos Menenakos ⁴ Abraham Pouliakis ² Ioanna Soula ¹ Sophia Anysiadou ¹ Ekaterini Domali ¹

¹1st Department of Obstetrics and Gynecology of Alexandra University Hospital, Medical School of Athens, Athens
²3rd Department of Obstetrics and Gynecology of Attikon University Hospital, Medical School of Athens, Athens
³General Surgery, Iaso General Epigonta Peristatika, Athens
⁴General Surgery, Eugendeio Therapeutrio, Athens
⁵General Surgery, Ealing Hospital, London

Abstract

Problem statement
Obesity is a global health problem affecting people across developed and developing countries, with approximately 650 million of all ages diagnosed worldwide. Studies have shown that obesity has an impact on fertility.

Methods
Research has shown that morbid obesity can effectively be treated by bariatric surgery and may also improve infertile women. The study included 32 patients and investigates the role of reproductive hormones, FSH (follicle-stimulating hormone), LH (luteinizing hormone), E2 (estradiol), free testosterone (FREE TESTO), AMH (anti-Müllerian hormone) and SHBG (sex hormone-binding globulin) with BMI before and after surgery. Additionally CART (cocaine and amphetamine-regulated peptide), an anorexic neuropeptide, and leptin were also studied in order to establish a possible relation between BMI reduction CART and leptin expression and hormone levels in infertile obese female patients under 40 years old.
Results
The study has shown that the mean reduction in BMI after the surgery was 16.03 kg/m2, with statistically significant differences observed (p-value <0.0001). We found significant changes in hormone levels following the surgery, FSH showed a mean difference of 3.18±1.19 before and after surgery, with a p-value of <0.0001, LH exhibited a mean difference of 2.62±1.1 before and after surgery, with a p-value of <0.0001, E2 levels demonstrated a mean difference of 18.62±5.02 before and after surgery, with a p-value of

Conclusion
The observed correlations may provide valuable insights into the factors influencing CART and leptin regulation in the context of obesity and bariatric surgery. These findings highlight the positive impact of bariatric surgery on BMI reduction and suggest a potential link between the surgical intervention, hormonal changes and gene expression.
There is no Disclosure of Interest in our study.

Table 1: Correlation between hormones and gene expression before and after bariatric surgery