SERUM LEVEL OF INTERLEUKIN-17, C-REACTIVE PROTEIN, AND URIC ACID AS PREDICTIVE BIOMARKERS IN EARLY-ONSET AND LATE-ONSET PREECLAMPSIA

Background: Preeclampsia (PE) is a complication of pregnancy that can increase maternal–fetal morbidity. The incidence of PE is seven times higher in developing country (WHO, 2019). Due to the high complexity of the pathogenesis, oxidative stress and inflammation are theorized to play a main role in PE. Oxidative stress and inflammation are influenced by various factors that could act as predictive biomarkers, such as interleukin (IL)-17, c-reactive protein (CRP), and uric acid. This study aims to compare serum levels of IL-17, CRP, and uric acid as predictive biomarkers in early-onset and late-onset PE.

Methods: A prospective comparative study with consecutive random sampling was conducted at the Department of Obstetrics and Gynecology RSMH Palembang from January through July 2022. A total of 90 pregnant women met theinclusion criteria and were divided into 3 groups, namely early-onset PE, late-onset PE, and normotension. Blood serum was examined once at the first visit. Differences in IL-17, CRP, and uric acid levels were analyzed with STATA version 15 using Kruskal-Wallis test, chi-square test and receiver operating characteristic.

Results: There were significant differences in IL-17 (59.12 pg/dl, 45.73 pg/dl, and 39.71 pg/dl, p=0.033), CRP (15.67mg/L, 10.19mg/L, and 3.69mg/L, p<0.001), and uric acid (7.57mg/dl, 5.66 mg/dl, and 4.18mg/dl, p<0.001)between the early-onset PE, late-onset PE, and normotension groups (p<0.05). Cut-offs of ≥66.31 and ≥66.84 pg/dL for IL-17, ≥5.70 and ≥5.90 mg/L for CRP, and ≥5.60 and ≥5.76 mg/dL for uric acid could be used to predict early- and late-onset PE, respectively.

Conclusion: The serum levels of IL-17, CRP, and uric acid could be used to predict early- and late-onset PE patients.